CD3 (immunology) - Wikipedia
CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). [1] It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains.
CD3 Antigen - an overview | ScienceDirect Topics
Anti-CD3 antibodies act as potent immunosuppressive agents by modulating the CD3/T-cell receptor (TCR) complex. They have been used in patients to prevent short term allograft rejection and were also shown to induce long-term remission of autoimmune diabetes in nonobese diabetic (NOD) mice [8] .
CD3-specific antibodies: a portal to the treatment of ...
2007年7月20日 · CD3-specific monoclonal antibodies have great potential as therapeutics for autoimmune diseases through the induction of immune tolerance. This Review discusses the current progress of the use...
CD3 Antibody - an overview | ScienceDirect Topics
The story of CD3 MAbs is paradoxical and remarkable. They were the first therapeutic antibody introduced in clinical practice in 1981, about 4 years before the molecular complexities and the key functional role of the CD3 molecule were discovered (Clevers et …
CD3: structure, function, and role of immunostaining in ...
CD3: structure, function, and role of immunostaining in clinical practice. J Pathol. 1994 Aug;173 (4):303-7. doi: 10.1002/path.1711730404.
Back on the scene: Advances and challenges in CD3-related ...
2022年8月1日 · CD3 molecules are mainly distributed on the membrane of mature T cells. They are involved in T cell antigen recognition, signal transduction, and regulation of T cell development. CD3-related monoclonal antibodies (mAbs) are mainly used in the treatment of autoimmune diseases.
CD3: Structure, function, and role of immunostaining in ...
Transformation of T cell lymphoma to large cell lymphoma. A clinicopathologic and immunologic study. Expression of B-cell antigens by Hodgkin's and Reed-Sternberg cells. Morphologic and immunologic characterization of 50 peripheral T-cell lymphomas.