B-lymphocyte antigen CD19, also known as CD19 molecule (Cluster of Differentiation 19), B-Lymphocyte Surface Antigen B4, T-Cell Surface Antigen Leu-12 and CVID3 is a transmembrane protein that in humans is encoded by the gene CD19.

CD19 is a biomarker for normal and neoplastic B cells, as well as follicular dendritic cells. CD19 is critically involved in establishing intrinsic B cell signaling thresholds through modulating both B cell receptor-dependent and independent signaling.

The CD19 antigen (aka B-lymphocyte antigen CD19 or Cluster of Differentiation 19) plays an important role in clinical oncology. It’s a protein found on the surface of B-cells, a type of white blood cell. Since CD19 is a hallmark of B-cells, the protein has been used to diagnose cancers that arise from this type of cell - notably B-cell ...

2024年12月24日 · CD19 (CD19 Molecule) is a Protein Coding gene. Diseases associated with CD19 include Immunodeficiency, Common Variable, 3 and Common Variable Immunodeficiency. Among its related pathways are Constitutive Signaling by Aberrant PI3K in Cancer and PIP3 activates AKT signaling.

CD19 is a 95 kDa transmembrane glycoprotein that belongs to the immunoglobulin superfamily and is expressed on B cells throughout most stages of B-cell differentiation. It forms a signal transduction complex and is commonly found in B cell–derived malignancies and …

2021年5月14日 · CD19 structure and signaling Clinical features Defects in CD19 cause immunodeficiency common variable type 3 ( OMIM #613493 ), characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen

CD19 is a pan-B cell marker that is recognized as a potential immunotherapy target for B cell disorders, including blood-borne malignancies and autoimmune diseases. Although initial attempts to target CD19 were unsuccessful, a new wave …

2019年11月13日 · Conclusions: CD19 and CD20 are both highly and consistently expressed in B-cell lymphomas. While CD20 has a higher average density of surface molecules per tumor cell, CD19 expression is more homogenous and is preserved in small CD20-negative tumor subsets and after anti-CD20 targeted therapy.

CD19 is a transmembrane glycoprotein member of the immunoglobulin superfamily. It consists of a single transmembrane domain, cytoplasmic C-terminus, and extracellular N-terminus. CD19 lacks structural homology with any known human proteins. CD19 is present on the surface of B-cells and is considered B-cell specific [3]. CD19 expression occurs ...

2017年1月5日 · CD19-targeted therapies based on T cells that express CD19-specific chimeric antigen receptors (CARs) or CD19/CD3 bispecific T-cell engagers (blinatumomab) have potent antitumor activity in patients with CD19 + lymphoma and leukemia. 2,3 However, CD19 – immune escape has emerged as a major mode of therapeutic resistance, especially for ...