CD16 - Wikipedia
CD16, also known as FcγRIII, is a cluster of differentiation molecule found on the surface of natural killer cells, neutrophils, monocytes, macrophages, and certain T cells. [1][2] CD16 has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b), which participate in signal transduction. [3] .
From CD16a Biology to Antibody-Dependent Cell-Mediated …
CD16a is a receptor for the Fc portion of IgGs and is responsible to trigger NK cell-mediated ADCC. The knowledge of the mechanism of action of CD16a gave rise to several strategies to improve ADCC, by working on either the mAbs or the NK cell.
CD16A Activation of NK Cells Promotes NK Cell Proliferation ... - PubMed
CD16A is a potent cytotoxicity receptor on human natural killer (NK) cells, which can be exploited by therapeutic bispecific antibodies. So far, the effects of CD16A-mediated activation on NK cell effector functions beyond classical antibody-dependent cytotoxicity have …
From CD16a Biology to Antibody-Dependent Cell-Mediated
2022年6月3日 · CD16a is a receptor for the Fc portion of IgGs and is responsible to trigger NK cell-mediated ADCC. The knowledge of the mechanism of action of CD16a gave rise to several strategies to improve ADCC, by working on either the mAbs or the NK cell.
The antibody-binding Fc gamma receptor IIIa / CD16a is N …
Among the five cognate activating FcγRs, FcγRIIIa/CD16a, is the primary target for engineered antibodies because it is primarily responsible for eliciting antibody-dependent cell-mediated cytotoxicity (ADCC) in natural killer cells (Wu et al., 2019). CD16a is heavily processed and contains five N-glycosylation sites.
NK cell CD16 surface expression and function is regulated by a ...
2013年5月2日 · CD16 (FCγRIII) binds to the Fc portion of IgG antibodies 11 ; one type, CD16A, is a transmembrane protein that co-localizes with CD3ζ and Fc-εRI-γ on NK cells. Upon ligation, it induces a potent series of signals resulting in cytokine production and …
Distinct CD16a features on human NK cells observed by flow …
2024年4月4日 · CD16a and ADCC are important components of treatments with many mAbs, including rituximab and trastuzumab 9, 10. The affinity of Fc-mediated antibody binding to CD16a affects both ADCC potency...
CD16 is indispensable for antibody-dependent cellular ... - Nature
2016年9月27日 · CD16, the FcγRIIIA, is essential for ADCC by NK cells, and is also expressed by a subset of human blood monocytes. We found that human CD16− expressing monocytes have a broad spectrum of ADCC...
Site-specific N-glycan Analysis of Antibody-binding Fc γ Receptors …
CD16a with hybrid and oligomannose type N-glycans bind IgG1 Fc with stronger affinity than complex type. FcγRIIIa (CD16a) and FcγRIIa (CD32a) on monocytes are essential for proper effector functions including antibody dependent cellular …
FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to ...
2022年1月23日 · FcγRIIIa (CD16a) is an activating Fc receptor and is mainly expressed by mast cells, macrophages, neutrophils, and NK cells [3, 4]. The activation of FcγRIIIa is in part dependent on its binding to the Fc portion of IgG1 antibody as shown in cocrystal structure of FcγRIIIa in complex with IgG .