The most important use of beta-lactamase inhibitors is in the treatment of infections known or believed to be caused by gram-negative bacteria, as beta-lactamase production is an …

2022年9月26日 · Beta-lactamase inhibitors are drugs that are co-administered with beta-lactam antimicrobials to prevent antimicrobial resistance by inhibiting serine beta-lactamases, which …

Beta-lactamase inhibitors are a class of medicine that block the activity of beta-lactamase enzymes (also called beta-lactamases), preventing the degradation of beta-lactam antibiotics. …

The newest effort to circumvent resistance is the development of novel broad-spectrum β-lactamase inhibitors that work against many problematic β-lactamases, including …

抑制剂 在作用于酶的过程中本身遭到破坏，因此此类酶抑制剂被称为“ 自杀性酶抑制剂 （Sucide Inhibitor）”。竞争性β-内酰胺酶抑制剂与底物竞争酶的催化部位，而通过与酶的某些点结合， …

Beta-lactamase inhibitors are antibiotics that block the activity of certain beta-lactamases and are thus sometimes combined with beta-lactam antibiotics. Examples include Clavulanate, …

Nacubactam, a novel β-lactamase inhibitor, presents two mechanisms of action: (I) inhibition of serine β-lactamases (classes A and C and some class D); (II) inhibition of penicillin-binding …

2024年10月19日 · Beta-lactamase inhibitors are a diverse group of compounds that enhance the efficacy of beta-lactam antibiotics by neutralizing the enzymes that degrade them. Among the …

2016年8月1日 · The newest effort to circumvent resistance is the development of novel broad-spectrum β-lactamase inhibitors that work against many problematic β-lactamases, including …

A beta-lactamase inhibitor used to prevent hydrolysis of beta-lactam antibiotics, leading to increased effectiveness. Sulbactam: An beta-lactamase inhibitor antibiotic combined with other …