Propagating Humanized BLT Mice for the Study of Human ...
2016年12月15日 · The humanized bone marrow-liver-thymus (BLT) mouse model harbors a nearly complete human immune system, therefore providing a powerful tool to study human immunology and immunotherapy.
Humanized mouse - Wikipedia
A humanized mouse is a genetically modified mouse that has functioning human genes, cells, tissues and/or organs. [1] Humanized mice are commonly used as small animal models in biological and medical research for human therapeutics.
BLT humanized mice as a small animal model of HIV infection
2015年8月1日 · BLT humanized mice are valuable models for the study of HIV infection. BLT mice recapitulate important aspects of human immunity, including T cell immunity. Various limitations in the model continue to exist. Recent approaches have improved engraftment and human immunity in the model.
Frontiers | The BLT Humanized Mouse Model as a Tool for ...
2022年5月19日 · Here, we provide the first characterization of γδ T cell-HIV interactions in bone marrow-liver-thymus (BLT) humanized mice and examined the immunotherapeutic potential of Vδ2 T cells in controlling HIV replication in vivo.
Propagating Humanized BLT Mice for the Study of Human ...
Humanized BLT mice that harbor a human immune system of HLA-A2 haplotype (denoted as BLT A2+) are valuable tools for studying HLA-A2-restricted T cell responses and developing T cell-based immunotherapies.
Using the BLT Humanized Mouse as a Stem Cell based Gene ...
2012年12月18日 · The modified BLT humanized mouse model coupled with in vivo PET imaging are powerful tools to study chronic human diseases. This system takes the BLT mouse model and advances it beyond the limited scope for HIV research.
An advanced BLT-humanized mouse model for extended HIV-1 …
TKO-BLT mice develop high-levels of multilineage hematopoiesis with organized lymphoid tissues and have an intact complement system. They exhibit hallmarks of human HIV-1 infection including CD4 + T-cell depletion and immune activation.