Androgen Receptor Structure, Function and Biology: From Bench …
The actions of androgens such as testosterone and dihydrotestosterone are mediated via the androgen receptor (AR), a ligand-dependent nuclear transcription factor and member of the steroid hormone nuclear receptor family.
Androgen receptor: structure, role in prostate cancer and drug ...
2014年6月9日 · Androgens and androgen receptors (AR) play a pivotal role in expression of the male phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate cancer,...
Androgen Physiology: Receptor and Metabolic Disorders
2021年7月2日 · The biological actions of testosterone and DHT are mediated by the androgen receptor, a member of the nuclear receptor superfamily, which in response to hormone regulates gene expression in target tissues.
Androgen Receptor - an overview | ScienceDirect Topics
An androgen receptor (AR) is a ligand-dependent nuclear transcription factor that mediates the action of androgens in the body, playing a crucial role in male sexual differentiation and physiology. You might find these chapters and articles relevant to this topic.
The Roles of Androgens in Humans: Biology, Metabolic Regulation …
The androgen receptor (AR) is a classical nuclear receptor, primarily acting through the selective induction of the translation of DNA strands to eventually synthetize specific proteins. The AR elicits the expression of a number of genes depending on the target cells and the modulation of …
Molecular Biology of the Androgen Receptor - Mayo Clinic …
The androgen receptor is a member of a superfamily of nuclear transcription factors that mediate the action of steroid hormones. When activated by ligand binding, these transcription factors bind to specific DNA sequences on target genes and regulate the transcriptional activity of …
Chemistry and Structural Biology of Androgen Receptor - PMC
Androgen receptor (AR) is a member of the steroid and nuclear receptor superfamily, 1 which is composed of over 100 members and continues to grow. Among this large family of proteins, only five vertebrate steroid receptors—estrogen, progesterone, androgen, glucocorticoid, and mineralocorticoid receptors—are known.
AR androgen receptor [Homo sapiens (human)] - Gene - NCBI
2024年11月14日 · The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor.
Androgen Receptor - SpringerLink
2016年12月19日 · The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a ligand-dependent transcription factor (TF) belonging to the steroid hormone receptor (SR) group of the nuclear receptor (NR) superfamily.
Structural Insights of Transcriptionally Active, Full-Length Androgen ...
2020年9月3日 · Androgen receptor (AR) is an androgen-activated transcription factor, which plays a key role in regulating expression of genes that are critical for male sexual development and differentiation, skeletal muscle growth, metabolism, nervous system development, as well as prostate cancer initiation and progression.
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