2022年10月18日 · Alpha-1 antitrypsin deficiency (sometimes just called “Alpha-1”) is an inherited genetic disorder that causes low levels of a protein (AAT) that protects your lungs. Alpha-1 increases your risk of developing certain diseases, including emphysema (damaged air sacs in your lungs), cirrhosis (liver scarring) and panniculitis (an uncommon skin ...

Alpha-1 antitrypsin deficiency is an inherited disorder that may cause lung disease and liver disease. The signs and symptoms of the condition and the age at which they appear vary among individuals. People with alpha-1 antitrypsin deficiency usually develop the first signs and symptoms of lung disease between ages 25 and 50.

Alpha-1 antitrypsin is the main protein of the alpha-globulin 1 region. Another name used is alpha-1 proteinase inhibitor (α 1 -PI). The gene is located on the long arm of chromosome 14 (14q32.1). Over 100 different variants of α 1 -antitrypsin have been described in various populations.

2024年8月17日 · Alpha-1 antitrypsin (AAT) deficiency is a genetically inherited condition characterized by the impaired production of the alpha-1 antitrypsin protein. This protein protects the body from neutrophil elastase, an enzyme released during inflammation and infection.

Alpha-1 antitrypsin deficiency (AATD) is an inherited disease that causes an increased risk of having chronic obstructive pulmonary disease (COPD), liver disease, skin problems (panniculitis), and inflammation of the blood vessels (vasculitis).

2024年5月3日 · Alpha-1 antitrypsin deficiency (AAT deficiency, or AATD) is an inherited condition that raises your risk for lung and liver disease. If you have this condition, your body doesn't make enough alpha-1 antitrypsin (AAT).

Alpha-1 antitrypsin deficiency (A1AD or AATD) is a genetic disorder that may result in lung disease or liver disease. [1] Onset of lung problems is typically between 20 and 50 years of age. [1] This may result in shortness of breath, wheezing, or an increased risk of lung infections.

2025年1月7日 · Alpha-1 antitrypsin (AAT) deficiency puts you at greater risk for lung, liver or skin disease. AAT is normally produced in the liver and travels through the blood to protect the lungs and liver from inflammation.

2023年5月18日 · Alpha-1 antitrypsin (A1AT) is a protein made by cells in the liver. It passes from the liver into the bloodstream and can travel to the lungs. Its main function is to protect the lungs from damage caused by other types of proteins called enzymes.

2006年10月27日 · Alpha-1 antitrypsin deficiency (AATD) can present with hepatic dysfunction in individuals from infancy to adulthood and with chronic obstructive lung disease (emphysema and/or bronchiectasis), characteristically in individuals older than age 30 years.