This essential structural and mechanical function is highlighted by the prominent distribution of desmosomes in tissues that are routinely subjected to physical forces, such as the heart and skin, and the wide range of desmosomal diseases that result from …

2008年3月1日 · Here we consider the structure, composition and function of desmosomes, and their role in embryonic development and disease. 1. Introduction. Desmosomes are intercellular junctions that provide strong adhesion between cells.

Defects in desmosomes cause diseases impacting the heart, epidermis, and other epithelia. In this review, we provide a historical perspective on the discovery of the desmosome and how the evolution of cellular imaging technologies revealed insights into …

2010年6月1日 · Desmosomes play important roles in the cell differentiation and morphogenesis of tissues. Studies on animal models have greatly increased our knowledge on epidermal development while reports on human developing skin are …

The essential function of the skin is that of a barriere against the outside. The epidermis is the tissue which assures the solidity and the resistance of the skin against forces of traction. The desmosomes, allowing the adhesion of epidermal cells, …

Desmosomes are important epidermal adhesion complexes that are characterized by a cell-specific expression of transmembrane cadherins and plaque-associated molecules. Desmosomes have so far, been implicated in three main disease types: autoimmune diseases that involve desmosome components (such as p …

Desmosomes are compromised in human diseases, including genetic disorders leading to blistering diseases of the skin, in cardiomyopathies and in some cancers. This review focuses on recent reports of desmosomal constituents in human disease and associated signaling mechanisms (Tables 1 and 2). Table 1.

The importance of desmosomes in tissue homeostasis is highlighted by natural and engineered mutations in desmosomal genes, which compromise the skin or heart and in some instances both. Desmosomal gene mutations account for 45-50% of cases of arrhythmogenic right ventricular cardiomyopathy, and are …

2013年1月1日 · The skin is the largest human organ. It has three layers: the epidermis, the dermis, and the hypodermis. The epidermis is the outer layer, formed by a stratified, squamous epithelium composed mainly of keratinocytes and also dendritic cells (melanocytes, Merkel cells, and Langerhans cells).

Desmosomes are cell–cell adhesions necessary for the maintenance of tissue integrity in the skin and heart. While the core components of desmosomes have been identified, peripheral components that modulate canonical or noncanonical desmosome functions still …