Akt/PKB activation and insulin signaling: a novel insulin signaling ...
Research in the field highlights Akt/PKB as a major signaling intermediate in insulin-stimulated glucose transport in type 2 diabetes characterized by reduced insulin signaling of Akt/PKB. 45, …
Role of PI3K/AKT Pathway in Insulin-Mediated Glucose Uptake
2018年11月5日 · In this chapter, we will focus on molecular events leading to GLUT4 translocation, starting with activation of insulin receptors through signaling cascade involving …
Insulin-induced Effects on the Subcellular Localization of AKT1, AKT2 ...
2016年12月14日 · The results revealed that: 1) insulin increased muscle membrane localization of AKT2, but not AKT1; 2) insulin increased AKT2 phosphorylation in the cytosol and membrane …
From insulin to Akt: Time delays and dominant processes
2020年12月21日 · Akt/PKB regulates numerous processes in the mammalian cell, including cell survival and proliferation, and glucose uptake in response to insulin. Abnormalities in Akt …
The PI3K/AKT pathway in obesity and type 2 diabetes - PubMed
2018年8月6日 · PI3K/AKT pathway damaged in various tissues of the body leads to obesity and type 2 diabetes as the result of insulin resistance, and in turn, insulin resistance exacerbates …
FoxK1 and FoxK2 in insulin regulation of cellular and ... - Nature
2019年4月5日 · Insulin induces Akt activation through IRS-1 and IRS-2 leading to the phosphorylation of FoxO1 which favors its translocation into the cytoplasm and binding to …
Insulin Regulates Adipocyte Lipolysis via an Akt-Independent …
2010年8月23日 · Akt inhibitor (Akti) completely reversed insulin's inhibition of lipolysis as stimulated by 25 or 50 nM isoproterenol, partially blocked insulin action at 6.26 or 12.5 nM …
Akt activation: A potential strategy to ameliorate insulin resistance ...
2019年10月1日 · Evidence has shown that PI3K-Akt/PKB pathway could be induced via insulin and act as an important effector. Akt/PKB is capable of inducing a great number of …
Trends in insulin resistance: insights into mechanisms and
2022年7月6日 · Insulin resistance (IR) is a disordered biological response for insulin stimulation through the disruption of different molecular pathways in target tissues.
Akt/PKB activation and insulin signaling: a novel insulin signaling ...
2014年2月13日 · Peripheral insulin action is reduced in type 2 diabetics whereas AMPK signaling remains largely intact. This paper firstly reviews AMPK and its role in glucose uptake and then …
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