2021年7月26日 · In addition, an adequate supply of GSH is beneficial to attenuate ferroptosis. Thiol supplementation with GSH selectively improves human endothelial dysfunction by enhancing NO activity .

2021年10月27日 · Glutathione peroxidase 4 (GPX4) inhibits ferroptosis through lipid hydroperoxides clearance. The expression or activity of GPX4 is influenced by glutathione (GSH), and GSH...

2020年2月3日 · Ferroptosis is a new type of programmed cell death, which occurs with iron dependence. Activating or blocking the ferroptosis pathway to alleviate the progression of the disease, which provides...

The GSH/SLC7A11/GPx4 axis is the most important defense axis of ferroptosis, and SLC7A11, as the upstream of the ferroptosis pathway, serves as the raw material for the synthesis of GSH through the uptake of cystine, whereas GSH, through the action of GPx4, is able to reduce lipid peroxides on the plasma membrane to lipids and alcohols, thus ...

2024年6月6日 · The GSH/SLC7A11/GPx4 axis is the most important defense axis of ferroptosis, and SLC7A11, as the upstream of the ferroptosis pathway, serves as the raw material for the synthesis of GSH through the uptake of cystine, whereas GSH, through the action of GPx4, is able to reduce lipid peroxides on the plasma membrane to lipids and alcohols, thus ...

2023年11月27日 · Glutathione (GSH) peroxidase 4 (GPX4) and GSH-independent ferroptosis suppressor protein 1 (FSP1) have been identified as major defenses. Here, we uncover a protective mechanism mediated by GSH S -transferase P1 (GSTP1) by monitoring proteinomic dynamics during ferroptosis.

2020年5月20日 · Peroxidation of polyunsaturated fatty acid of phospholipids causes ferroptosis. Peroxidation is initiated from traces of LOOH decomposed by ferrous iron. Traces of LOOH are the fallout of oxidative metabolism and lipoxygenase activity. Lipid peroxidation is primed when GPx4 becomes insufficient to maintain homeostasis.

2020年5月20日 · Ferroptosis (FPT) is a form of cell death due to missed control of membrane lipid peroxidation (LPO). According to the axiomatic definition of non-accidental cell death, LPO takes place in a scenario of altered homeostasis. FPT, differently from apoptosis, occurs in the absence of any known specific …

2024年6月6日 · This study aimed to elucidate the intricate relationship between GSH metabolism and ferroptosis, highlighting how modulation of GSH metabolism can impact cellular susceptibility to ferroptosis and consequently influence the development of tumors and other diseases.

2023年4月1日 · Cellular redox balance, particularly the GSH/GSSG redox ratio, which often works closely with thioredoxin redox, is essential for redox control and cell ferroptosis. We also recognize that cells have evolved a complex series of processes to regulate when and how ferroptosis is initiated, and that they use this cell death type to inhibit ...