C-C chemokine receptor type 7 - Wikipedia
C-C chemokine receptor type 7 is a protein that in humans is encoded by the CCR7 gene. [ 5 ] Two ligands have been identified for this receptor: the chemokines (C-C motif) ligand 19 (CCL19 /ELC) and (C-C motif) ligand 21 (CCL21). [ 6 ] The ligands have similar affinity for the receptor, though CCL19 has been shown to induce internalisation of ...
CCR7 and its ligands: balancing immunity and tolerance
CCL19 and CCL21 are the sole ligands for the CC-chemokine receptor 7 (CCR7), which is expressed by various subsets of immune cells 1. CCR7 and its ligands are essentially involved in homing of...
The Multi-Functional Roles of CCR7 in Human Immunology and as …
2022年7月6日 · The CC-chemokine receptor 7 (CCR7) provides a significant contribution in guiding cells to and within lymphoid organs and is important for acquiring immunity and tolerance. The CCR7 holds great importance in establishing thymic architecture and function and naïve and regulatory T-cell homing in the lymph nodes.
CCL19 and CCR7 Expression, Signaling Pathways, and Adjuvant Functions ...
2019年10月1日 · Vpu specifically interacts and colocalizes with CCR7 in the trans-Golgi network in which CCR7 is retained. The stimulation of HIV-1-infected primary CD4+T cells with CCL19 reduces mobilization of Ca2+, reduces phosphorylation of Erk1/2, and impairs migration toward CCL19 (Ramirez et al., 2014).
C-C Chemokine Receptor 7 in Cancer - PMC - National Center for ...
2022年2月14日 · Overall, expression of CCR7 can promote metastasis to bone, skin or lymph nodes; the mechanisms regulating the migration of tumors to different sites are unclear [56,57,65]. In most forms of breast cancer, expression of CCR7 correlates with decreased 5 year survival and tumor recurrence [60,61,65].
CCR7 as a therapeutic target in Cancer - PubMed
The CCR7 chemokine axis is comprised of chemokine ligand 21 (CCL21) and chemokine ligand 19 (CCL19) acting on chemokine receptor 7 (CCR7). This axis plays two important but apparently opposing roles in cancer.
Common and biased signaling pathways of the chemokine receptor CCR7 ...
2016年1月4日 · One of the most important chemokine receptors for adaptive immune cell migration is the CC-chemokine receptor CCR7. CCR7 and its ligands CCL19 and CCL21 control homing of T cells and dendritic cells to areas of the lymph nodes where T cell priming and the initiation of the adaptive immune response occur.
CCL19 and CCR7 Expression, Signaling Pathways, and Adjuvant …
2019年10月1日 · Migration of CC-chemokine receptor 7 (CCR7)-expressing cells to secondary lymphoid organs is a crucial step in the onset of adaptive immunity, which is initiated by a complex interaction between CCR7 and its cognate ligands.
CCR7 Gene - GeneCards | CCR7 Protein | CCR7 Antibody
2024年10月1日 · GeneCards Summary for CCR7 Gene. CCR7 (C-C Motif Chemokine Receptor 7) is a Protein Coding gene. Diseases associated with CCR7 include Chronic Graft Versus Host Disease and Pars Planitis. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.
CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic …
2019年3月19日 · CCR7 chemokine receptor stimulation induces rapid but transient dendritic cell (DC) migration toward draining lymph nodes, which is critical for the initiation of protective immunity and maintenance of immune homeostasis.