Heart conditions: Syrian rue contains the chemicals harmaline and harmine. These might cause complications in people who have a slow heart rate or heart disease.

2025年1月22日 · The beta-carboline alkaloids are the most studied and the most pharmacologically active constituents and include harman, harmine, tetrahydroharmine, harmalol, harmol, and harmaline, which are reversible and competitive inhibitors of MAO-A.

2024年8月5日 · Harmine: This is the most studied alkaloid found in Syrian Rue. It appears as a highly fluorescent compound under UV light and is known for its strong MAO-A inhibitory properties. Harmaline: Harmaline is similar to harmine but slightly more potent in its activity. Harmaline also serves as a reversible inhibitor of MAO-A.

Harmine is a beta-carboline and a harmala alkaloid. It occurs in a number of different plants, most notably the Syrian rue and Banisteriopsis caapi. [3] Harmine reversibly inhibits monoamine oxidase A (MAO-A), an enzyme which breaks down monoamines, making it a Reversible inhibitor of monoamine oxidase A (RIMA). Harmine does not inhibit MAO-B. [4]

One study shows that harmine regulates the expression of peroxisome proliferator-activated receptor gamma (PPARγ), the main regulator of adipogenesis and the molecular target of the thiazolidinedione antidiabetic drugs, through inhibition of the Wnt signaling pathway.

Slow heart rate and heart disease: Syrian rue contains the chemicals harmaline and harmine. These chemicals might cause complications in people who have a slow heart rate or heart disease. People with these conditions should avoid taking Syrian rue.

Harmine is a beta-carboline alkaloid well-known for giving Ayahuasca its hallucinogenic effects. Its main sources are the wild plants Peganum harmala (Syrian rue) and Banisteriopsis caapi, which are noted for their therapeutic value.

2 天之前 · Harmine is a β-carboline alkaloid derived from Peganum harmala, showing a solid antitumor potential in different types of human cancer cells. Unfortunately, the clinical application of this natural alkaloid has been impeded till now by severe toxic side effects, especially neurotoxicity, besides its poor water solubility. Therefore, over the recent years, several …

Harmine is a highly potent inhibitor of dual-specificity tyrosine-phosphorylation regulated kinase (DYRK). Harmine has been reported to have antidepressant-like actions in rodents. Harmine possesses anxiolytic, behavioral effects and anti-tumor potential both in vitro and in vivo.

2020年11月18日 · Compared with harmine, harmine derivatives exhibited similar pharmacological effects such as neuroprotective, antitumor, pest and parasite control, and antiviral effects, conferring higher activity and lower neurotoxicity.