DNA Gyrase as a Target for Quinolones - PMC - PubMed Central …
Bacterial DNA gyrase is a type II topoisomerase that can introduce negative supercoils to DNA substrates and is a clinically-relevant target for the development of new antibacterials. DNA …
Quinolone-Binding Pocket of DNA Gyrase: Role of GyrB - PMC
DNA gyrase is a prokaryotic type II topoisomerase and a major target of quinolone antibacterials. The majority of mutations conferring resistance to quinolones arise within the quinolone …
DNA Gyrase as a Target for Quinolones - PubMed
2023年1月27日 · Bacterial DNA gyrase is a type II topoisomerase that can introduce negative supercoils to DNA substrates and is a clinically-relevant target for the development of new …
The DNA Gyrase-Quinolone Complex - Journal of Biological Chemistry
We demonstrate that quinolone binding and drug-induced DNA cleavage are separate processes constituting two sequential steps in the mechanism of action of quinolones on DNA gyrase. …
The DNA gyrase-quinolone complex. ATP hydrolysis and the ... - PubMed
1998年8月28日 · Quinolone binding to the gyrase-DNA complex induces a conformational change that results in the blocking of supercoiling. Under these conditions gyrase is still capable of …
The Complex of DNA Gyrase and Quinolone Drugs on DNA …
2000年12月15日 · Quinolone drugs can inhibit bacterial DNA replication, via interaction with the type II topoisomerase DNA gyrase. Using a DNA template containing a preferred site for …
Molecular Mechanisms of DNA Gyrase Inhibition by Quinolone ...
1994年1月1日 · The objective of this chapter is to summarize data on quinolone action against DNA gyrase that have led to the proposal of a hypothetical model for quinolone inhibition, and …
DNA Gyrase as a Target for Quinolones - ResearchGate
2023年1月27日 · Bacterial DNA gyrase is a type II topoisomerase that can introduce negative supercoils to DNA substrates and is a clinically-relevant target for the development of new …
Interaction between DNA Gyrase and Quinolones: Effects of …
Using a drug-binding assay we demonstrated that the double-mutant enzyme-DNA complex has a lower affinity for ciprofloxacin than the wild-type complex. Based on the pattern of resistance to …
DNA gyrase, topoisomerase IV, and the 4-quinolones
1997年9月1日 · The key event in quinolone action is reversible trapping of gyrase-DNA and topoisomerase IV-DNA complexes. Complex formation with gyrase is followed by a rapid, …