The Notch signaling pathway plays major roles in organ development across animal species. In the mammalian liver, Notch has been found critical in development, regeneration and disease. …

2022年1月21日 · Nakano et al. report that two distinct Notch signals regulate the progression of hepatocellular carcinoma (HCC) using tissue specific loss of function mouse mutants. They …

2014年4月1日 · In the liver, Notch signaling is involved in biliary tree development and tubulogenesis. Recent advances have shed light on Notch as a critical player in liver …

Persistent activation of Notch signaling is associated with liver malignancies, such as hepatocellular carcinoma with stem cell features and intrahepatic cholangiocarcinoma. The …

Persistent activation of Notch signaling is associated with liver malignancies, such as hepatocellular carcinoma with stem cell features and intrahepatic cholangiocarcinoma. The …

2024年10月8日 · We revealed a crucial role for the Notch-Recombination signal binding protein for immunoglobulin kappa J region (RBPJ) signaling pathway in controlling the monocyte-to …

In the mammalian liver, bile is transported to the intestine through an intricate network of bile ducts. Notch signaling is required for normal duct formation, but its mode of action has been …

2018年8月2日 · These findings show that Notch signaling is crucial for mediating EPC function under both physiological and pathological conditions in the liver. Notch signaling also mediates …

2013年11月1日 · Notch signalling in the liver. 1. In the liver, a Notch ligand (Jag-1) expressing cell activates Notch-1 or Notch-2 on the surface of the Notch receptor expressing cell. 2. Upon …

2019年10月14日 · The Notch signaling pathway plays major roles in organ development across animal species. In the mammalian liver, Notch has been found critical in development, …