Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation.

Rap1 is activated by extracellular signals through several regulatory proteins, and it might function in diverse processes, ranging from modulation of growth and differentiation to secretion,...

Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation.

The Rap1 signaling is clearly shown to play a role in tumor promotion, through the activation of other signaling pathways such as MAPK/ERK, Src/FAK, or other novel pathways which have not been elucidated.

The Rap1 signaling pathway offers many targets for novel clinical tools given that Rap1 affects not only cell polarity and cell adhesion but also cell proliferation and invasion. Treatment with the demethylating agent 5-aza-2'-deoxycytidine induces Rap1GAP expression and reduces melanoma cell proliferation and survival 25 .

2019年12月13日 · We show that RAP1 interacts with many members of the DNA damage response (DDR) pathway. RAP1 depleted cells show reduced interaction between XRCC4/DNA Ligase IV and DNA-PK, and are impaired...

A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.

Activated downstream from their receptors, Rap1 promotes signaling pathways leading to activation of Erk, Akt, Rac1 and Afadin, thereby regulating endothelial cell proliferation, migration, and tubule formation [29, 34].

What Is the Rap1 Signaling pathway? In the Rap1 signaling pathway, the activation of Rap1 by some stimuli recruits many effectors, leading to its involvement in integrin signaling, ERK activation, and other important cellular processes.

2007年1月1日 · Recently, the Rap1 signalling pathway has been found to play a crucial role in the regulation and maintenance of cell-cell contacts. The present review focuses on the evidence that led to the appreciation of Rap1 as a master regulator of cell-cell junctions.