Nuclear receptor - Wikipedia
Nuclear receptors are multifunctional proteins that transduce signals of their cognate ligands. Nuclear receptors (NRs) may be classified into two broad classes according to their mechanism of action and subcellular distribution in the absence of ligand.
15. Nuclear Receptors – Principles of Pharmacology – Study Guide
Nuclear receptors are receptors located inside the cell. These receptors are found either in the cytoplasm (Type I) or the nucleus (Type II) of a cell. Examples include: estrogen, glucocorticoids, thyroid hormone T3 or vitamins D and A. Receptor stimulation of any intracellular receptor primarily results in altered gene transcription.
Tackling exosome and nuclear receptor interaction: an emerging …
2024年9月26日 · Accumulating evidence emphasizes the regulatory role of exosome-derived microRNAs (miRNAs) in chronic inflammation, disease progression, and therapy resistance, primarily by modulating transcription factors, particularly NRs.
The nuclear receptor superfamily | Journal of Cell Science | The ...
2003年2月15日 · Nuclear receptors are one of the most abundant classes of transcriptional regulators in animals (metazoans). They regulate diverse functions, such as homeostasis, reproduction, development and metabolism (for a review, see Laudet and Gronemeyer, 2002).
Nuclear receptors: from molecular mechanisms to therapeutics
2021年11月26日 · Nuclear receptors are classically defined as ligand-activated transcription factors that regulate key functions in reproduction, development, and physiology. Humans have 48 nuclear receptors, which when dysregulated are often linked to diseases.
A Key Transcription Factor Family: Nuclear Receptors
2020年10月30日 · Nuclear receptors (NRs) reside either in the cytoplasm (AR and GR) in a complex with chaperone proteins, such as HSP, or are already located in the nucleus (most other nuclear receptors), when they are activated through the binding of their specific lipophilic ligand.
Visualizing the Architectures and Interactions of Nuclear Receptors
2016年11月1日 · Here, we review the new structural advances together with proteomic discoveries that shape our understanding of how NRs form a variety of functional interactions with collaborating factors in chromatin.
Nuclear Receptors: Recent Drug Discovery for Cancer Therapies
2019年3月14日 · Nuclear receptors (NRs) are transcription factors actively involved in many aspects of human physiology and pathology, serving as sensors of stimuli, master regulators of downstream molecular events, and hubs governing complex gene regulatory networks.
Nuclear Receptors: From Structure to the Clinic | SpringerLink
Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins.
Nuclear Receptors: A new mode of inhibition - eLife
2024年8月19日 · Complementary structural biology approaches reveal how an agonist and a covalent inhibitor simultaneously bind to a nuclear receptor.