NAPQI, also known as NAPBQI or N-acetyl-p-benzoquinone imine, is a toxic byproduct produced during the xenobiotic metabolism of the analgesic paracetamol (acetaminophen). [1] It is normally produced only in small amounts, and then almost immediately detoxified in the liver.

NAPQI is the toxic metabolite of Acetaminophen . NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in …

Inhibition of glutathione synthetase (GS) by N-acetyl-p-benzoquinone imine (NAPQI) could contribute to 5-oxoprolinuric acidosis in such patients. We investigated the interaction of NAPQI with GS in vitro.

NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver.

N -acetyl- p -benzoquinoneimine (NAPQI), a toxic byproduct of paracetamol (Acetaminophen, APAP), can accumulate and cause liver damage by depleting glutathione and forming protein adducts in the mitochondria. These adducts disrupt the respiratory chain, increasing superoxide production and reducing ATP.

2024年12月4日 · The paracetamol metabolite N-acetyl-4-benzoquinoneimine (NAPQI) prevents modulation of K V 7 channels via G-protein coupled receptors by interference with PIP 2 and Ca 2+ sensitivity

In humans, between 5% and 15% of a paracetamol dose is metabolized through cytochrome P450 enzymes (mainly CYP2E1 and CYP3A4) to N-acetyl-p-benzoquinone imine (NAPQI), which is known to mediate hepatotoxicity after paracetamol over dosage. 34 Less than 0.01% of paracetamol is converted to N-arachidonoylphenolamine (AM404) through conjugation of ...

2024年12月3日 · Paracetamol has been found to alleviate inflammatory pain by modulating K V 7 channels. Its metabolite N-acetyl-4-benzoquinoneimine (NAPQI) increases currents through these channels via a stretch of three cysteine residues in the channel S2–S3 linker. Through this effect, the excitability of neurons in the pain pathway is dampened.

分配实验的结果表明，NAPQI是对乙酰氨基酚的主要代谢产物，其中相当一部分迅速还原为对乙酰氨基酚。 N-乙酰基-对苯醌亚胺（NAPQI）在过去的10年中被认为是对乙酰氨基酚的有毒代谢产物，尽管它从未被检测为对乙酰氨基酚的酶促氧化产物。 我们报告（i）通过细胞色素P-450和氢过氧化异丙苯直接检测作为对乙酰氨基酚的氧化产物而形成的NAPQI，以及（ii）间接证据表明，对乙酰氨基酚通过细胞色素P-450，NADPH和NADPH-细胞色素形成了NAPQI P-450还原酶。 …

据文献报道，对乙酰氨基酚（apap）的反应性代谢产物n-乙酰基-对苯醌亚胺（napqi）可以迅速芳构化并氧化木瓜蛋白酶家族的巯基（半胱氨酸）蛋白酶，从而在其发病机理中形成加合物。