Recent advances in understanding the role of IL-4 signaling
2021年9月7日 — Interleukin-4 (IL-4) is a four-α-helical bundle type I cytokine with broad pleiotropic actions on multiple lineages. Major actions of IL-4 were initially discovered for B and T cells, but this cytokine acts on more than a dozen different target cells spanning the innate and adaptive immune systems a …
Regulation of inflammation by interleukin-4: a review of …
Keywords: alternative splicing, interelukin-4 receptor, interleukin-4 signaling, alternative macrophage activation. Abstract. Studies of IL-4 have revealed a wealth of information on the diverse roles of this cytokine in homeostatic regulation and disease pathogenesis.
Interleukin - StatPearls - NCBI Bookshelf
2022年8月22日 — Interleukin-4 (IL-4) CD4+T cells (Th2) synthesize IL-4, and it acts on both B and T cells. It is a B-cell growth factor and causes IgE and IgG1 isotype selection. It causes Th2 differentiation and proliferation, and it inhibits IFN gamma-mediated activation on macrophages. It promotes mast cell proliferation in vivo. Interleukin-5 (IL-5)
Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 …
2018年6月6日 — Interleukin-4 and IL-13 are the signature cytokines of the type II inflammatory response. They are key players in the inflammatory response triggered either by an invading parasite or allergen.
Interleukin 4 - an overview | ScienceDirect Topics
Interleukin-4 is a cytokine that is produced by various cells and plays a role in exerting anti-inflammatory effects during infections like tuberculosis. AI generated definition based on: Tuberculosis, 2009
Evolution and function of interleukin-4 receptor signaling in …
2020年3月6日 — Woytschak J, Keller N, Krieg C, Impellizzieri D, Thompson RW, Wynn TA, et al. Type 2 interleukin-4 receptor signaling in neutrophils antagonizes their expansion and migration during infection...
THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions
Interleukin-4 is a multifunctional cytokine that plays a critical role in the regulation of immune responses. Its effects depend upon binding to and signaling through a receptor complex consisting of the IL-4Rα chain and the common gamma chain (γc), resulting in a series of phosphorylation events mediated by receptor-associated kinases.
Regulation of IL4 gene expression by T cells and therapeutic ...
2003年7月1日 — Interleukin-4 (IL-4) is a key cytokine that controls the differentiation of T helper (T H) cells to the T H 2 effector cells that are responsible for cellular immunity and inflammation.
IL-4 in the Brain: A Cytokine To Remember
2012年11月1日 — Interleukin-4 induces proliferation and activation of microglia but suppresses their induction of class II major histocompatibility complex antigen expression.
Recent advances in understanding the role of IL-4 signaling
Interleukin-4 (IL-4) is a four-α-helical bundle type I cytokine with broad pleiotropic actions on multiple lineages. Major actions of IL-4 were initially discovered for B and T cells, but this cytokine acts on more than a dozen different target ...
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