Glucuronidation - Wikipedia
Glucuronidation occurs mainly in the liver, although the enzyme responsible for its catalysis, UDP-glucuronyltransferase, has been found in all major body organs (e.g., intestine, kidneys, brain, adrenal gland, spleen, and thymus).
Glucuronidation - an overview | ScienceDirect Topics
Glucuronidation is a process where glucose is used for conjugation, playing a significant role in endogenous and xenobiotic metabolism by forming glucuronides that are excreted in bile and urine. It involves enzymes called glucuronosyl transferases and can be reversed by bacterial glucuronidase in the colon and bladder.
Glucuronidation: Detox, Balance Hormones, & Genes
2021年11月3日 · Glucuronidation is an important detoxification reaction that inactivates and detoxifies estrogens, hormones, neurotransmitters, drugs, mold toxins, and cancer-causing toxins. In this post, we’ll explain glucuronidation and factors that increase or decrease it.
Glucuronidation - an overview | ScienceDirect Topics
Glucuronidation, which involves the covalent addition of glucuronic acid to a chemical, is an elimination and detoxification mechanism for a host of lipophilic compounds that includes drugs, environmental chemicals, and endobiotics.
Glucuronidation - an overview | ScienceDirect Topics
Glucuronidation is a conjugation reaction whereby glucuronic acid, derived from cofactor UDP-glucuronic acid, is covalently linked to a substrate containing a nucleophilic functional group. The resultant metabolite, called a glucuronide, is excreted in bile and urine.
Glucuronidation: driving factors and their impact on ... - PubMed
Glucuronidation involves the metabolism of parent compound by UDP-glucuronosyltransferases (UGTs) into hydrophilic and negatively charged glucuronides that cannot exit the cell without the aid of efflux transporters.
Challenges and Opportunities with Predicting in Vivo Phase II ...
Glucuronidation, which is catalyzed by UDP-glucuronosyltransferases (UGTs), is a major metabolism and detoxification pathway of drugs in humans and in mammals. It was reported in 2002 that glucuronidation is an important clearance mechanism for approximately 1 in 10 of the top 200 prescribed drugs.
Drug glucuronidation in humans - PubMed
Glucuronidation is a major metabolic pathway for a large number of drugs in humans. Conjugation of drugs and other chemicals with glucuronic acid is catalyzed by the multigene UDP-glucuronosyltransferase family.
Glucuronidation: driving factors and their impact on ...
2017年5月22日 · Glucuronidation involves the metabolism of parent compound by UDP-glucuronosyltransferases (UGTs) into hydrophilic and negatively charged glucuronides that cannot exit the cell without the aid of efflux transporters.