Within the field of developmental biology, one goal is to understand how a particular cell develops into a final cell type, known as fate determination. Within an embryo, several processes play out at the cellular and tissue level to create an organism.

2024年5月6日 · Understanding and manipulating cell fate determination is pivotal in biology. Cell fate is determined by intricate and nonlinear interactions among molecules, making mathematical model-based...

Cell fate is determined through a coordinated activity of transcription factors (TFs) and chromatin-remodeling complexes that establish a chromatin landscape that defines the gene products necessary for the specific function of that cell.

2025年1月15日 · The fate of a cell describes its future identity, or the identity of its daughter cells, before it is actually phenotypically detectable through differentiation or division.

Cells must “decide” whether to replicate, differentiate, or die. These cellular decisions are a critical aspect of organismal development, wound healing, and immune systems. However, cells may not “choose” the ideal fate in the case of diseases, such as cancer.

The choice of a cell's fate affects all aspects of its behavior, defining a cell's morphology, migratory status, and proliferation and the competence to do a range of specific functions associated with its differentiated state.

We will briefly introduce some notions from dynamical systems theory, and discuss how they offer a framework within which to build a rigorous understanding of what we mean by a cell “fate”, and how cells change fate.

5 天之前 · Cell fate plasticity enables development, yet unlocked plasticity is a cancer hallmark. While transcription master regulators induce lineage-specific genes to restrict plasticity, it remains ...

To date, one of the most intriguing and compelling concepts to impact contemporary cell biology is the notion that cell fate is “programmed” or genetically controlled. Indeed, the regulation of cell fate is crucial for embryonic development, and tissue homeostasis.

5 天之前 · Cell fate determination can involve either (1) translocation of hexokinase-II (HKII) to the mitochondrial outer membrane (OMM) due to activation of the PI3K/Akt/GSK-3β pathway, leading to cytoprotection, or (2) translocation of BAX to OMM as part of the apoptotic pathway, leading to cell death. Signaling convergence for both HK-II and BAX is interaction with the voltage …

Cell fate refers to the process that determines how many times a cell divides, influenced by stem cells, precursor cells, cell cycle exit, and apoptosis. It is regulated by cell fate determining genes like Hox genes and involves interactions between cells.

Here, we summarize recent insights into how cell fate decisions are influenced by four aspects of cell biology: metabolism, reactive oxygen species (ROS), intracellular pH (pHi), and cell morphology. For each topic, we discuss how these cell biological cues interact with each other and with protein-based mechanisms for changing gene transcription.

This review highlights how alternative splicing (AS) shapes cell fate, covering its regulatory impact on proliferation, cell cycle, differentiation, apoptosis, and oncogenesis.

2024年5月6日 · Understanding and manipulating cell fate determination is pivotal in biology. Cell fate is determined by intricate and nonlinear interactions among molecules, making mathematical model-based quantitative analysis indispensable for its elucidation.

On its path from a fertilized egg to one of the many cell types in a multicellular organism, a cell turns the blank canvas of its early embryonic state into a molecular profile fine-tuned to achieve a vital organismal function.

We will briefly introduce some notions from dynamical systems theory, and discuss how they offer a framework within which to build a rigorous understanding of what we mean by a cell "fate", and how cells change fate.

Understanding the molecular events that regulate how cells that contain the same genetic information can generate non-equivalent states or different cell fates has been a topic of fascination for biologists for over 100 years.

2019年12月12日 · We will briefly introduce some notions from dynamical systems theory, and discuss how they offer a framework within which to build a rigorous understanding of what we mean by a cell “fate”, and how cells change fate.

2022年1月19日 · Recent work shows how molecular “noise” can shape the architecture of this landscape and how universal properties of cell fate commitment can be distilled from careful consideration of its geometry.

Cell fate determination (see Glossary), wherein less differentiated cells progressively acquire specific fates and functions, is essential for proper embryogenesis and maintenance of postnatal tissue homeostasis by stem cells.

In this review, we discuss recent advances in understanding the role of metabolism, reactive oxygen species (ROS), intracellular pH (pHi), and cell morphology and adhesions to cell fate decisions, particularly during differentiation in adult, embryonic, and …

2025年2月11日 · MIT Professor Xiao Wang’s research is focused on developing tools that pinpoint where in a cell different types of messenger RNA are translated into proteins — information that can offer insight into how cells control their fate and what goes wrong in disease.

2017年10月13日 · The choice of a cell's fate affects all aspects of its behavior, defining a cell's morphology, migratory status, and proliferation and the competence to do a range of specific functions associated with its differentiated state.

2025年2月6日 · An artist's impression of cancer cells. peterschreiber.media/iStock / Getty Images Plus. A critical transition, the researchers explain, is when a radical change in state occurs at a specific ...

Surface modification plays an essential role in dictating cell behavior and fate, as it creates a microenvironment that profoundly influences cell attachment, migration, proliferation, and differentiation. This review aims to the intricate interplay of culture surface properties, including topography, stiffness, charge, and chemical ...