Apoptosis regulator BAX - Wikipedia
Apoptosis regulator BAX, also known as bcl-2-like protein 4, is a protein that in humans is encoded by the BAX gene. [5] BAX is a member of the Bcl-2 gene family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities.
Bax-induced apoptotic cell death - PNAS
2000年1月18日 · In a recent issue of PNAS, Khaled and colleagues have addressed how cells might accomplish this fine-tuning of the apoptosis cascade by analyzing the regulation of the proapoptotic molecule Bax in response to the withdrawal of growth factors.
BAX Gene - StatPearls - NCBI Bookshelf
2020年9月11日 · The BAX gene (Bcl-2 Associated X-protein) is a pro-apoptotic member of the Bcl-2 gene family; it encodes a 21-kDa protein named BAX-alpha, whose association with Bcl-2 researchers believe plays a critical role in regulating intrinsic apoptosis.
Bax, Bak and beyond - mitochondrial performance in apoptosis
Bax and Bak are members of the Bcl-2 family and core regulators of the intrinsic pathway of apoptosis. Upon apoptotic stimuli, they are activated and oligomerize at the mitochondrial outer membrane (MOM) to mediate its permeabilization, which is considered a key step in apoptosis.
The pro-apoptotic BAX protein influences cell growth and ...
BAX (namely, BCL-2-Associated X protein) was the first identified pro-apoptotic member of the BCL-2 protein family. 1 The majority of BAX proteins are found in the cytoplasm in a closed / globular conformation in healthy cells. 2 BAX is one of the gatekeepers that control mitochondrial outer membrane permeabilization during apoptosis.
Building blocks of the apoptotic pore: how Bax and Bak are
2013年10月25日 · Two key members of the Bcl-2 family are the proapoptotic proteins Bax and Bak, which convert from harmless monomers into deadly oligomers that form pores in the MOM. These pores are conduits for...
Bax-induced apoptosis shortens the life span of DNA repair …
Bax is a 21 kDa protein that is known to play an essential role in programmed cell death (PCD) or apoptosis. 1,2 Bax belongs to the Bcl-2 family of proteins, which are an evolutionarily conserved family of proteins controlling cell death. 1,2 Bax resides in the cytosol in healthy cells, but Bax translocates from the cytosol to mitochondria in ...
BAX and BAK dynamics control mitochondrial DNA release during apoptosis
2022年3月26日 · BCL2 associated X, apoptosis regulator (BAX) and BCL2 antagonist/killer 1 (BAK1, best known as BAK) are key mediators of intrinsic apoptosis, a regulated cell death (RCD) pathway that is...
Mitochondrial residence of the apoptosis inducer BAX is more …
2020年2月2日 · The BCL-2–associated X apoptosis regulator (BAX) protein critically contributes to this process by forming pores in the mitochondrial outer membrane. However, the relative roles of the mitochondrial residence of BAX and its oligomerization in promoting membrane permeabilization are unclear.
Chemical modulation of cytosolic BAX homodimer potentiates BAX …
2023年12月16日 · Using the inactive BAX dimer structure and a pharmacophore-based drug screen, we identify a small-molecule modulator, BDM19 that binds and activates cytosolic BAX dimers and prompts cells to...