Allostatic load is "the wear and tear on the body" which accumulates as an individual is exposed to repeated or chronic stress. The term was coined by Bruce McEwen and Eliot Stellar in 1993. It represents the physiological consequences of chronic exposure to fluctuating or heightened neural or neuroendocrine response which results from repeated ...

In allostatic load, it is the accumulation over time of the “wear and tear on a number of organs and tissues” that leads to physiological dysregulation and ultimately, via allostatic overload, to physical or mental illness.

The findings indicate that allostatic load and overload are associated with poorer health outcomes. Assessment of allostatic load provides support to the understanding of psychosocial determinants of health and lifestyle medicine.

2022年8月11日 · When events occur that exceed an individual's capacity to cope, allostatic overload may occur. Allostatic load was introduced by neuroendocrinologist Bruce McEwen and psychological psychologist Eliot Stellar in 1993. McEwen described allostatic load as the price people pay for adapting to stress.

2020年10月26日 · Allostatic overload occurs when the cumulative effects of physiological stress response lead to health problems, disease, or death. This is why it’s estimated that...

Allostatic load is a measure of physiological dysregulation due to the cumulative burden of chronic stress on the body. This dysregulation is caused by the excess secretion of hormones such as catecholamines and glucocorticoids in response to chronic stressors.

Allostatic load is a measure of physiological dysregula-tion due to the cumulative burden of chronic stress on the body. This dysregulation is caused by the excess secretion of hormones such as catecholamines and glu-cocorticoids in response to chronic stressors.

2020年12月28日 · Introduction: Allostatic load refers to the cumulative burden of chronic stress and life events. It involves the interaction of different physiological systems at varying degrees of activity. When environmental challenges exceed the individual ability to cope, then allostatic overload ensues.

2024年8月18日 · At its core, allostatic load is the cumulative wear and tear on the body’s systems as they strive to maintain balance in response to ongoing stressors. To fully grasp this concept, we must first understand the relationship between allostasis and homeostasis.

The biologic responses to stressors have been collectively called allostatic load, a summary measure of major perturbations in the autonomic, endocrine, and immune systems. Allostatic load has been linked to accelerated aging, worsened immunologic tolerance, ineffective defense systems, and increased cardiovascular morbidity.