Portal hypertension is elevated blood pressure in your portal vein and the smaller veins that branch off from it — your portal venous system. The portal venous system drains blood from your stomach, intestines, pancreas and spleen into your liver through the portal vein.

The close relationship between the spleen and liver is reflected in the concept of the hepatosplenic axis. The spleen is a regulatory organ that maintains portal flow into the liver and is the key organ in the forward flow theory of portal hypertension. This review summarizes the literature on the role of the spleen in portal hypertension.

2002年2月1日 · Relationship between spleen size, evuated with U5 as bipolar diameter, and portal pressure, evaluated as hepatic venous pressure gradient (HVPGI measured during hepatic vein catheterization (on left), and between spleen size and portal vascular resistance measured as HVP6 divided by portal blood flbw measured with echoDoppler fon right), in 54 ...

AIM: To determine an optimal cutoff value for abnormal splenic artery diameter/proper hepatic artery diameter (S/P) ratio in cirrhosis-induced portal hypertension. METHODS: Patients with cirrhosis and portal hypertension (n = 770) and healthy ...

The possible relationships between splenomegaly and portal hypertension have been analysed in patients with cirrhosis. In this condition, splenomegaly is not only caused by portal congestion, but it is mainly due to tissue hyperplasia and fibrosis. The increase in …

In portal hypertension, a local hyperdynamic state occurs around the spleen. Splenomegaly is associated with a poor prognosis in cirrhosis and is caused by spleen congestion and by enlargement and hyperactivation of splenic lymphoid tissue.

2024年9月23日 · Spleen stiffness measurement by vibration-controlled transient elastography at 100 Hz for non-invasive predicted diagnosis of clinically significant portal hypertension in patients with compensated advanced chronic liver disease: a modelling study

2023年7月18日 · The presence of clinically significant portal hypertension (defined by a hepatic venous pressure gradient >10 mm Hg) in patients with compensated advanced chronic liver disease (ACLD) identifies a subgroup of patients who are at increased risk of decompensation and developing hepatocellular carcinoma.1,2 Use of carvedilol reduces portal ...

Portal hypertension (PHT) is characterised by an abnormal elevation in the pressure difference between the portal vein and hepatic venous system. 1 It is the primary cause of the development of main complications observed in cirrhosis patients, such as variceal haemorrhage, ascites and hepatic encephalopathy, causing a high risk of mortality and...

2025年1月13日 · The spleen-to-liver stiffness ratio (SLR) has emerged as a valuable non-invasive tool for distinguishing NCPF from CLD and predicting clinical outcomes in patients with portal hypertension. By combining spleen and liver stiffness measurements, clinicians can more accurately assess disease severity and stratify patients based on their risk of ...