The lymph nodes of the hepatic chain receive afferents from the stomach, duodenum, liver, gall-bladder, and pancreas; their efferents join the celiac group of preaortic lymph nodes.

In lymph nodes, LyECs induce CD8 T-cell deletion through LAG-3/MHC-II signaling with expression of MHCII type self-antigens as well as through PD-1/PD-L1 signaling. The regulation of immune cells by LyECs is largely unexplored in liver disease.

2015年1月12日 · This study examined the impact of cancer that has spread to the liver and the lymph nodes surrounding the liver (hepatic hilar lymph node [HLN] metastasis) on patient survival.

2023年5月23日 · In one small study of people with metastatic hepatocellular carcinoma, those whose liver cancer had spread to their lymph nodes or distant organs had an average survival rate of 4 and 11...

The deep portal lymphatics converge at the liver hilum and drain into a complex network of peripancreatic and paraaortic lymph nodes that ultimately connect with the cisterna chyli and thoracic duct [5–9].

Functionally, circulating lymphocyte subsets play immune surveillance roles by patrolling blood, lymph nodes, and other secondary lymphoid organs, whereas the liver-resident lymphocytes reside in the liver sinusoidal blood, and focus on the hepatic homeostatic maintenance and immune defenses.

2023年10月30日 · Lymphatics from the posterior surface of the liver drain into celiac/superior mesenteric or posterior mediastinal lymph nodes. Ultimately, lymph reaches the right lymphatic and thoracic duct.

2024年12月6日 · The superior surface of the liver also has communications with extraperitoneal lymphatics that perforate the diaphragm and drain into mediastinal lymph nodes 9. Innervation The liver is supplied by sympathetic and parasympathetic autonomic fibers from the hepatic plexus via the celiac plexus , which travel with branches of the hepatic artery ...

The hepatic nodes consist of the hepatic, receiving lymph from the celiac nodes and located on the hepatic artery; the subpyloric, a group of four to five nodes at the bifurcation of the gastroduodenal artery; and the cystic nodes, on the neck of the gallbladder.

The liver produces a large amount of lymph, which is estimated to be 25 to 50 % of lymph flowing through the thoracic duct. The hepatic lymphatic system falls into three categories depending on their locations: portal, sublobular, and superficial lymphatic vessels.