The authors performed extensive coarse-grained molecular dynamics simulations of 140 different prion-like domain variants to interrogate how specific amino acid substitutions determine the driving ...
Prions represent a new class of infectious agents which propagate on a protein-only level, not requiring agent-encoded nucleic acids. Newly emergent prion diseases such as bovine spongiform ...
Interestingly, the fluidity of the plasma membrane also depends on caveolae fusion with the plasma membrane (Sohn et al., 2018; Yang et al., 2020). Whether, in prion-infected neurons, the freezing of ...
Many questions surround the underlying mechanism for the differential metabolic processing observed for the prion protein (PrP) in healthy and prion-infected mammals. Foremost, the physiological ...
Alzheimer's disease and other forms of dementia are characterised by toxic clumps of faulty proteins. Some rare forms of dementia, including Creutzfeldt-Jakob disease (CJD) are caused by a type of ...
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