For example, knockdown of TUBB2C sensitizes all PDAC cell lines to vincristine by initiating apoptosis in tumor cells. Further examination showed elevated sensitivity to other vinca alkaloids, ...

Department of Chemical and Biological engineering, School of Engineering and Technology, National University of Mongolia, Ulaanbaatar 14201, Mongolia ...

Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, People’s Republic of China ...

FIGURE 1. Quinolizidine alkaloid biosynthetic pathway: all QAs are derived from lysine. Enzymes involved in the pathway are L/ODC, copper amine oxidase (CuAO), and two acyltransferases ...