MSCs also impair the expansion, cytokine secretion, and cytotoxic activity of proinflammatory CD8 + T cells. Moreover, MSCs inhibit the differentiation, proliferation, and antibody secretion of B ...

The recovered cells were viable, as indicated by their ability to exclude the vital dye Trypan blue (data not shown), and were able to secrete similar quantities of TGF-β, IL-10, IL-4 or IFN-γ ...

To overcome the immunosuppressive TME of GBM several strategies to engineer allogeneic CAR T cells can be used: secretion of pro-inflammatory cytokines (such as IL-7, IL-12, IL-15, IL-21, or IL-23), ...

A) Pathway analysis using GO term for cellular compartment shows significant enrichment of Paneth cell genes in glial-depleted mice. B) Schematic of explant assay used to analyze Paneth cell secretion ...

Despite this, the role of IL-17 in bone pathology is poorly understood. This study aimed to investigate IL-17 signalling in the context of pathological bone formation. Methods A biomimetic human ...

A more detailed study of the β-glucans zymosan, β-1,3 glucan and β-1,3/1,6 glucan showed that these β-glucans ... In co-cultures of dendritic cells with mouse T cells sensitized to the major birch ...

It is likely that IL-17 expression in IBD may be associated with altered immune and inflammatory responses in the intestinal mucosa. Inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) ...

Pathogen-fighting immune cells called tissue-resident memory CD8 T cells (TRM cells) go through a surprising transformation -- and relocation -- as they fight infections in the small intestine.

1Department of Obstetrics and Gynecology, Peking University Third Hospital, China 2Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China. 3Biobank, Peking ...

To find the skin care that dermatologists recommend, go to: Relief for skin problems related to cutaneous T-cell lymphoma. Baggot M, Stadler R. “Cutaneous lymphoma.” In: Kang S, et al. Fitzpatrick’s ...