These target OMA-1, a mitochondrial protein that is part of the integrated stress response pathway. In healthy cells, OMA-1 is an important mediator of cell health from within the mitochondria.

If there are specific pathways, then there might be opportunities to manipulate them. In recent years, genes involved in ER stress and the related signaling networks have emerged as potential loci ...

This study shows that PACAP38 leads to stress-induced migraines through the MrgprB2-Mast cell pathway and not through other receptors like PAC1, as previously thought. Treatments that block ...