The decrease in CD4 cells during HIV infection seems to be ... and higher LPS levels were associated with greater activation of CD8 + lymphocytes. CD8 + activation also was found to be higher ...

which transduced most T cells with balanced distribution to CD4+ and CD8+ cells. Untargeted LNPs did not elicit T cell transduction. The biodistribution of ctLNP-mRNA to the liver, spleen ...