Epigenetic modifications such as DNA methylation and histone acetylation contribute to the profibrotic phenotype of SSc fibroblasts. It has been shown that DNA methylation and histone ...

SLC25A1 drives citrate export from the mitochondria to the cytosol, where it fuels acetyl-CoA synthesis by ATP citrate lyase (ACLY). This acetyl-CoA supply sustains FSP1 acetylation and prevents its ...

Sirtuin 5 (SIRT5), a member of the sirtuin family ... Firstly, the discovery of SIRT5’s non-acetylation-related enzymatic activities is relatively recent compared to its deacetylase function, which ...

Billions of dollars have been invested over the past two decades in efforts to upregulate sirtuin enzymes due to their role in regulating healthspan and lifespan. The biotechnology company Sirtris ...