The histone deacetylases HDAC type I (1-3) and the family of Sirtuins type III, have been identified to mediate protein delactylation (Moreno-Yruela et al, 2022). Next, we determined which ...

Epigenetic modifications such as DNA methylation and histone acetylation contribute to the profibrotic phenotype of SSc fibroblasts. It has been shown that DNA methylation and histone ...

Mechanistically, 8C reduced I/R injury by promoting histone acetylation which in turn activated the expression of antioxidant genes and inhibited cardiomyocyte (CM) apoptosis. Furthermore, we ...

These findings highlight the biological significance of lysine fatty acylation and sirtuin-catalyzed protein lysine defatty-acylation. To investigate whether K-Ras4a could also be regulated by SIRT2 ...