This study investigates the molecular mechanisms underlying chronic pain-related memory impairment by focusing on S1P/S1PR1 signaling in the dentate gyrus (DG) of the hippocampus. Through behavioral ...

This observation represents the basis of the work where the authors identify the sphingosine receptor S1PR1 as down-regulated in the dentate gyrus of susceptible animals and demonstrate through an ...

BACKGROUND: BAF312 (Siponimod) is a dual agonist at the ... and calcium signalling as well as S1PR1 internalization and cytokine levels was investigated using Western blotting, immunochemistry ...

CEO and President Michael Anderson told listeners that the internalization and rebranding marks “a significant milestone that we believe will enhance our operational efficiency, further align our ...

Paul Hudson, CEO, Novartis Pharmaceuticals, said: “Siponimod is the first investigational medicine to show a significant delay in disability progression in typical SPMS patients.