To edit the assembly code, use IDA pro 7.2 and do your changes there, that way they can be backed up easier. There are a few misceelaneous commands for the processor. Output your file via the LST file ...
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If wishing to make a signature in one of the disjointed chunks, try using the "At address" method. If all else fails, try a "From address range" sig (which might take some manual searching for ...