The hypothesis and design of the SHOCK trial have been previously published. [9] Figure 1 outlines the trial design. The trial aimed to test the superiority of a strategy of early committed ...
In this trial, cardiogenic shock was defined as clinical evidence of systemic hypoperfusion with systolic blood pressure <90 mm Hg for at least 30 minutes (or the need for supportive measures to ...
Istaroxime has been studied in four positive Phase 2 trials enrolling patients with acute heart failure and early cardiogenic shock due to heart failure. “We are pleased that istaroxime is ...