That change was linked to a rise in a modified form of cholesterol known as oxysterol. Lowering oxysterol, in both animal models and human stem cells, freed the trapped ABCA1 and restored the pathway ...

The National Academies of Sciences, Engineering, and Medicine are private, nonprofit institutions that provide expert advice on some of the most pressing challenges facing the nation and world. Our ...

This opioid pathway in the brain was specifically activated when the mice ate additional sugar, but not when they ate normal or fatty food. When the researchers blocked this pathway, the mice ...

Pathway Sports and Entertainment, a new company “focused on monetizing athlete NIL rights,” is launching into the space by “providing players with four-figure guarantees as part of video game NIL ...

The Economic Mobility Pathways Pilot (EMPP) is a program for skilled refugees and displaced people looking to work permanently in Canada. The EMPP: helps skilled refugees and other displaced people ...

A STAT5 dimer translocates to the nucleus and changes rates of transcription. STAT5 signaling is attenuated by the protein suppressors of cytokine signaling (SOCS)3 and protein inhibitor of ...

A recent Brazilian study published in Nature Cardiovascular Research has highlighted promising pathways for preventing and treating atrial fibrillation, a condition that significantly raises the ...

Using SPICE, we successfully identified known composite elements, such as AP1-IRF composite elements (AICEs) and STAT5 tetramers, and also uncovered several novel binding partners, including JUN-IKZF1 ...

TCPTP can dephosphorylate JAK1 and JAK3, as well as STAT1, STAT3, STAT5, and STAT6 (molecules in blue), whereas it is not identical in different cytokine signaling according to summary of existing ...

Figure 2. Signaling pathways up and downstream of mTOR complexes. Upon growth factors- or cytokine-mediated activation, three major pathways are initiated: the Jak-Stat5 pathway, the PI(3)K-Akt-mTOR ...