These two proteins together with TBC1 domain family member 7 (TBC1D7) protein form a TSC complex, negatively regulate the biological target Rheb protein of mTORC1 ... we reported that the ...

Long-term, low-dose cannabis treatment has been shown to reverse brain aging and enhance cognitive abilities in mice by modulating the protein switch mTOR, which plays a critical role in cellular ...

We further find decreased mTORC1 signaling activity and c-Myc levels at low pH. Mechanistically, nuclear/cytoplasmic acidification is linked to mTORC1 suppression in a Rheb-, Akt/TSC2/PRAS40-, GATOR1- ...

The sperm epigenome is shaped in a compartment protected by the blood-testes barrier (BTB) known to deteriorate with age. Permeability of the BTB is regulated by the balance of two mTOR complexes in ...

Notably, the emergence of SMC-derived luminal myofibroblasts—in both mice and patients with KD, Takayasu’s arteritis and Giant Cell arteritis—coincided with activation of the mechanistic target of ...

Here, we describe how the extracellular signal-regulated kinase (ERK) pathway in osteoblasts controls bone formation by suppressing the mechanistic target of rapamycin (mTOR) pathway. We also show ...