Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.

Despite the established links between inflammation and cancer development, the effects of inflammatory signaling on cancer ...

On a recent winter afternoon in downtown Truckee, the sun dipped behind the mountains as a full moon rose above Donner Pass Road, the California city’s main thoroughfare. As the temperature ...

More recently, quantitative proteomics analyses uncovered the heterogeneity of Western AML patients at ... molecular characteristics of Acalisib (PI3K inhibitor) resistance. In the Spearman ...

Regor Pharmaceuticals Inc. has divulged phosphatidylinositol 3-kinase (PI3K) inhibitors reported to be useful for the treatment of cancer, congenital lipomatous overgrowth, vascular malformations, ...

Aromatase is an enzyme that converts testosterone to estradiol, a type of estrogen. One study found that taking an estrogen blocker called an aromatase inhibitor while on testosterone therapy reduced ...

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Western firms face costly exit conditions in Russia Trump's return may alter exit strategies for multinationals Asset seizure risk remains for companies staying in Russia LONDON/MOSCOW, Jan 20 ...

With its latest acquisition, Lilly will carve out a spot in the PI3K inhibitors space in breast cancer, which for long was dominated by Novartis’ Piqray (alpelisib). In October 2024, Roche had a ...

The texture, the music, and the whole aura of these films are completely different, and when a Western film is on, you know it’ll surely be an adventurous ride full of action. Considering the growing ...