The manuscript addresses the 3D chromatin architecture in monocytes from patients with alcohol-associated hepatitis and its relationship to enhanced transcription of innate immune genes. While the ...

Work at the University of Florida has led to the identification of nuclear receptor subfamily 1 group D member 1 (Rev-erbA-α) antagonists reported to be useful for the treatment of cancer, sarcopenia ...

此外，此前研究发现缺失 NR2F6 可增强 T 细胞的抗肿瘤反应，尤其是在免疫检查点抑制期间。本研究进一步表明，在 NK 细胞中缺失 NR2F6 对于缺乏有效 T 细胞表位或下调 MHC-I 表达以逃避免疫监视的肿瘤可能具有重要意义，为联合治疗干预提供了潜在途径。然而，NKp46 表达增强在自身免疫性疾病如系统性红斑狼疮（SLE）中的作用仍有待进一步研究，需要深入探讨 NK 细胞上 NKp46 ...

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...

Discover the role of phytoestrogens, including soy, in menopause management and breast cancer prevention. Learn how these ...

This prospective case-control study included 85 patients with lung involvement related to the COVID-19 virus and a group of ...

Dosage-sensitive sex reversal adrenal hypoplasia congenital critical region on X chromosome gene 1, DAX1, also known as NR0B1, is a less well characterized orphan nuclear receptor that has been ...

The bile salt, nuclear farnesoid X receptor (FXR), was recently implicated in intestinal antibacterial defence and barrier function. The aim of this study was to investigate the therapeutic potential ...

Nuclear and solar energy, which Stargate also highlights, are increasingly emerging as viable answers to that question. How will these energy sources converge to address AI’s energy dilemma?

There were no calamitous new developments last year with respect to nuclear weapons—but this is hardly good news. Longstanding concerns about nuclear weapons—involving the modernization and expansion ...

It was a secret nuclear-powered city built deep within a glacier. Its true legacy is only now being revealed. Workers test one of the polar station’s 15 escape hatches. When this image and ...