Therefore, drug targets that act in the brain, specifically on the central component of the trigeminovascular system, the TCC, would seem to be ideally placed to modulate this nociceptive pathway ...

Sensory pathways in Drosophila to detect and avoid 2MT are shown. Flies escape from 2MT through olfactory, taste, and nociceptive sensory pathways. This study identified that TRPA1 expressed in ...

According to this view, migraine nociception arises not from extracranial ... to movement and physical exercise, and the neural pathways that underlie these phenomena remain to be elucidated.

in an olfactory pathway, and direct contact with 2MT activates TRPA1 in taste and nociceptive pathways. This resulted in apparent avoidance of the chemical source by male flies and avoidance of ...

Gastric pain has limited treatment options and the nociceptive ascending pathway remains largely unclear. Here, the authors identify a glutamatergic tetra-synaptic NTS–LPB–PVT–PL circuit ...

Box 1. Glossary. Aβ-fibers: large-myelinated nerve afferents or pathways that convey non-nociceptive input (e.g., tactile sensation) Aδ-fibers: small-myelinated nerve afferents or pathways ...