Neuroscience research has increasingly focused on the role of autophagy in maintaining neuronal health and metabolism. Neurons, with their complex architecture and post-mitotic nature, require ...

Dr. Sajad Zalzala, chief medical officer of AgelessRx in Michigan, helps people live their longest, healthiest lives. He ...

Mitochondria play an essential role in maintaining cellular health. When damaged, they are removed through a recycling ...

DNA damage repair machinery is not robust in full-grown mammalian oocytes. Here, the authors demonstrate that mammalian oocytes fail to activate autophagy in response to DNA DSBs, correlating with ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Autophagy mediates the degradation of harmful ...

Parkinson’s disease (PD) is a major and progressive neurodegenerative disorder, yet the biological mechanisms involved in its aetiology are poorly understood. Evidence links this disorder with ...

Damaged mitochondria are selectively eliminated by mitophagy. Parkin and PINK1, gene products mutated in familial Parkinson’s disease, play essential roles in mitophagy through ubiquitination of ...