The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway plays a key role in immune response and inflammation. More and more studies demonstrated that JAK/STAT ...

Protein concentration was determined using the BCA protein concentration determination kit. Western blot was used to detect apoptosis and protein expression of JAK2/STAT3 signaling pathway, as ...

School of Life Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China ...

ORLANDO -- More than 40% of patients with longstanding prurigo nodularis (PN) had significant improvement within 3 months of ...

Do you know the nuances between the JAK-STAT pathway and atopic dermatitis? Check your knowledge with this quick quiz.

研究人员针对 JAK/STAT 信号通路与铁死亡（Ferroptosis）的关系展开研究，发现其在多种疾病中作用关键，为治疗提供新思路。 铁死亡（Ferroptosis），一种近年来备受瞩目的调节性细胞死亡方式，因其在癌症、神经退行性疾病等多种病症中的关键作用，成为了生命 ...

Janus kinase (JAK) inhibitors look to be a good treatment option for the newly recognized, rare autoimmune disease known as ...

SASP factors secreted by senescent cells activate the JAK-STAT3 and NF-kB pathways in non-senescent tumor cells, promoting proliferation, therapy resistance and SASP spreading. Senescent tumor cells ...

为解决 JAK - STAT 基因错义突变研究的空白问题，研究人员对比 COSMIC 和 All of Us 数据库开展研究。结果发现突变分布特征及三类突变。该研究有助于理解突变影响，推动个性化医学发展，推荐科研读者阅读。 在基因的奇妙世界里，有一种叫做单核苷酸多态性 ...

这项研究发现指出了提高癌症疗法效果的新途径，提升了CAR-T细胞疗法治疗血液癌症（如淋巴瘤和白血病）的可能性。改进后的CAR-T细胞不仅能更好地抵御肿瘤，还能在体内保持长期活性，从而降低癌症复发的风险。目前，研究人员正在探索是否可以用相同的基因修饰方法来治疗其他类型的癌症，特别是实体瘤，尽管用当前的方法治疗这些肿瘤仍面临挑战。