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J VIROL. | 自噬在非洲猪瘟病毒感染早期促进 p72 降解和衣壳分解
在这篇文章中,作者发现在ASFV感染的早期阶段,自噬促进了p72的降解和衣壳的分解。从机制上讲,Stub1通过HSPA8促进ASFV p72的多泛素化。多泛素化的p72随后与自噬受体SQSTM1 / p62相互作用,导致其通过选择性自噬途径降解。这些发现揭示了p72通过自噬降解的机制 ...
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