It has since become clear that AAV is actually a ‘dependovirus’ that can only be produced with assistance from other helper viruses. AAV offers a number of advantages for gene therapy ...

Safe and effective gene therapy strategies depend on robust and reliable adeno-associated virus (AAV) mediated therapeutic gene delivery. However, scaling up AAV manufacturing to obtain sufficient ...

To address this bottleneck, Seymour and colleagues developed a new way to manufacture rAAV using the ‘helper’ adenovirus ... needed to generate new AAV particles; in its late phase, it ...