Portal hypertension is an abnormal increase in blood pressure defined clinically as hepatic venous pressure gradient 5 mmHg in the hepatic portal vein system. Causes of portal hypertension ...

Child's paper, "The Portal Circulation," which appeared in the ... listed by the author as indicating a more favorable state of hepatic compensation is to be encouraged. In average hospital ...

Hypothesis: It is unknown whether hepatic impairment (HI) impacts pelacarsen uptake and systemic exposure. Aim: This single-dose, open-label, parallel-group, Phase 1 study (NCT05026996) assessed the ...

The antiphospholipid syndrome associated with hepatic vein thrombosis has usually been of the primary type; that is, the American Rheumatism Association criteria for the diagnosis of systemic ...

We recently identified N-methyl-2-pyridone-5-carboxamide (2PY), the main end product of nicotinamide in human, as a pro-steatotic metabolite markedly elevated in hepatic steatosis conditions. The ...

A distinctive feature, however, is the association with intrahepatic or subcapsular hepatic venous collateral vessels. This collateral circulation is the most sensitive feature for the diagnosis ...

Here, we report an innovative nanocapsule-based drug delivery system that synergizes its own biological effect (stimulation of GLP-1 release) and that of the encapsulated bioactive molecule (exenatide ...

Nov. 13, 2024 — The Huntington's disease (HD) mutation eventually causes a fatal brain disease in adulthood, but a new study finds that early in life, children with the HD mutation have bigger ...

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Since the discovery of statins and the Scandinavian Simvastatin Survival Study (4S) results three decades ago, remarkable advances have been made in the treatment of dyslipidaemia, a major risk factor ...

Organ systems work together to keep the body in good health. For example, the circulatory and digestive systems work jointly to deliver nutrients throughout the body. Except for the reproductive ...