When this approach was applied to blood samples from children with thalassemia, it appeared as though there was unequal labeling of the α- and β-globin chains. The problem was that there was no ...

γ(G16D) was designed to have a higher affinity for α-globin, with the intention of outcompeting the mutated β-sickle chains and increasing fetal hemoglobin formation. Comparative studies of ...