Tumor cells transform fibroblasts into cancer-associated fibroblasts, which have an important immunosuppressive activity on which growth, invasion, and metastasis depend. These activated fibroblasts ...

These 3D cell culture platforms have been applied to answer questions of fundamental biological ... expansion and differentiation of bone marrow derived mesenchymal stem cells for applications in ...

A study provides insights into the diversity of cancer-associated fibroblasts in white and black skin cancer and describes their different immunomodulatory roles in the tumor environment.

Our research focuses on the tumor-permissive molecular mechanisms underlying cancer-associated fibroblast function as well as immune suppression ... including mouse models of pancreatic cancer, ...

"Older fibroblasts release proteins that directly affect pancreatic cancer cells and ultimately lead to the growth and spread ...