A new study highlighting the importance of a large protein complex called the exocyst in cell growth, division and communication reveals new functions and mechanisms that are essential to how ...

More information: Chanwoo Lee et al, Exocyst stimulates multiple steps of exocytic SNARE complex assembly and vesicle fusion, Nature Structural & Molecular Biology (2024). DOI: 10.1038 ...

The exocyst was discovered as a tethering complex mediating initial encounter of arriving exocytic vesicles with the plasma membrane. The exocyst complex is regulated by Rab and Rho small GTPases, ...

As the world is severely affected by COVID-19 pandemic, the use of chloroquine and hydroxychloroquine in prevention or for the treatment of patients is allowed in multiple countries but remained at ...

This important work identifies a non-autophagic role for ATG5 in lysosomal repair and the trafficking of the glucose transporter GLUT1 to the cell surface, mediated through the retromer complex. The ...

Exocytosis, the fusion of secretory vesicles with the plasma membrane to allow release of the contents of the vesicles into the extracellular environment, and endocytosis, the internalization of ...

The exocyst complex is a crucial player in the process of exocytosis, which is the mechanism by which cells transport and release substances to the outside environment. This complex is composed of ...