引言衰老是生物体经历的系统性功能衰退过程，与神经退行性疾病、代谢失调和癌症等年龄相关疾病密切相关。蛋白质稳态（proteostasis）的丧失是衰老的重要分子特征之一，而自噬（autophagy）在维持细胞稳态及调节蛋白质降解过程中起核心作用。自噬主 ...

The interplay between TLR signalling, autophagy and antigen presentation merits further investigation. Although the above examples all rely on macroautophagy, chaperone-mediated autophagy also ...

A GP practice has been criticised after a patient said she felt “forced” to undergo a gynaecological exam with a “chaperone” present in the room. The patient said she was “embarrassed ...

Meanwhile, they released β-syn peptides, which, through the activation of chaperone-mediated autophagy pathways, cleared α-syn aggregates, reducing pathological fibrils. Ultimately, the ATB NPs ...

Meanwhile, they released β-syn peptides, which, through the activation of chaperone-mediated autophagy pathways, cleared α-syn aggregates, reducing pathological fibrils. Ultimately, the ATB NPs ...

In addition, they release β-syn peptides, which, through the activation of chaperone-mediated autophagy pathways, clear α-syn aggregates, reducing pathological fibrils. Ultimately, the ATB NPs ...

State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province ...

1Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul, Republic of Korea. 2Department of Biomedical Sciences, College of Medicine, Seoul National University, ...

More than 50 students at Napa’s Justin-Siena High School have been working to bring “The Drowsy Chaperone” to life. The show, which opens Thursday night, is a musical comedy that ...

Henan Key Laboratory of Environmental and Animal Product Safety, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan,China ...

There is evidence for the occurrence of programmed cell death (PCD) in several neurodegenerative disorders. Most of the evidence comes from studies in animal models of conditions such as Parkinson ...

There are three main forms of autophagy, chaperone-mediated autophagy, microautophagy and macroautophagy, among which macroautophagy is the most common. Microautophagy directly wraps the substrate to ...