Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China Esophageal cancer (EC) is among the most aggressive malignancies, ranking as the seventh most prevalent ...

A woman was left shocked after taking a DNA test to learn more about her heritage - only to discover that she has a long-lost sibling. But her discovery ended up 'ruining' his life A woman was left ...

The findings were recently published in Communications Chemistry. p53 is central to the body's defense against cancer, tasked with regulating the cell cycle and triggering the death of damaged ...

1 Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China 2 Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, ...

Fighting cancer is exhausting for T cells. Hostile tumor microenvironments can drain their mitochondrial activity, leading to a condition known as T cell exhaustion. This phenomenon also hinders ...

Journal of Nuclear Medicine September 2024, jnumed.124.267736; DOI: https://doi.org/10.2967/jnumed.124.267736 ...

While it has been known that mutations in the CDCA7 gene cause ICF syndrome, little was known about the gene's molecular function. Now Rockefeller University's Funabiki lab, in close collaboration ...

科学家们已经确定，CDCA7基因对于识别和促进部分甲基化DNA区域的修复是必要的。细胞分裂周期相关7 (CDCA7)基因的突变与不当的DNA甲基化有关，导致免疫缺陷、着丝粒不稳定和面部异常(ICF)综合征等疾病。研究人员发现，CDCA7在识别DNA的半甲基化区域和招募解旋酶 ...

Researchers found that valproic acid (VPA), especially when combined with DHA, significantly reduces SARS-CoV-2 infection rates and severity, potentially activating antiviral mechanisms ...

DNA methylation, a process by which methyl groups are added to DNA molecules, is essential for the maintenance of DNA and the overall health of an organism. Understanding why CDCA7-HELLS is crucial ...

The absence of HELLS or its activator, cell division cycle associated 7 (CDCA7) is known to be a factor that leads to the disruption of DNA methylation. Mutations in the genes that code for HELLS and ...