This important study provides solid evidence to support the anti-tumor potential of citalopram, originally an anti-depression drug, in hepatocellular carcinoma (HCC). In addition to their previous ...

derived macrophages from 10 healthy human blood donors. In brief, PBMCs were cultured in RPMI medium for 24–48 h before treating with 5 ng/mL GM-CSF for 3 days. Adherent cells were further treated ...

Division of Physiological Chemistry and Metabolism, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-0011, Japan Laboratory of Metabolomics, RIKEN Center for Integrative ...

Using lineage tracing, we find that tissue-resident red pulp macrophages (RPM), initially depleted by BCG exposure, are restored from both tissue-trained, self-renewing macrophages and from bone ...

Classical monocyte-derived macrophages in ANCA-associated glomerulonephritis express inflammatory cytokines and chemokines, driving local inflammation. The presence of macrophage subtypes with ...

We hypothesized that IL-10 has dose-dependent effects on macrophage (Mφ) phenotypic transition and cardiac remodeling after ... For M1 polarization, we labeled cells with a primary rat anti-mouse CD86 ...

The study introduces an innovative tracer targeting CD163, a molecular receptor on tumor-associated macrophages—immune cells that support tumor growth and protection. The tracer is based on ...